You've done your homework

You researched and you have an early draft, what next.....

With the early draft, you have to remember that players will get hurt and others will lose their starting jobs. You have to keep that in mind when drafting players like Fred Taylor. So before you get started, make a list of players by position in order that you like them.

For example
LT
Adrian Peterson
Brian Westbrook
Joseph Addai
..............

On your list, you want to give certain players a certain level. For example the ones I listed, I might have as my #1 studs. Do this for every position and try and get a player in each postion listed as #1. This might be difficult, especially if you draft 10th, but if you are 10th, and every #1 RB is gone, but you have a #1 WR out there, you dont want to reach for a #2 RB.

The secret of drafting is being flexible. If you have the 10th pick, you aren't going to get Tomlinson, Addai, Westbrook, and hey if they are there, you have a slam dunk. Most of the time they are not slam dunks. You have to make choices, and this list will help you. With the 10th pick , Marion Barber, Clinto Portis, Willie Mcgahee probably will be there. Each of them are not studs and have risk, so you look at what else is there, maybe not in a RB, you have TO, Reggie Wayne, as it is right now, if I had to pick with those 3 RBS there, I would take Marion Barber and MCGahee is he was there afterwards. TO is no young chicken and I've been burned by him in the past and with Manning being hurt, not sure I am aboard the Reggie Wayne train as a first rounder anyway.

You have to be flexible when drafting, what you think will happen might not, and even though you want to draft a wr, you might not be able to. As a rule, especially in the first couple of rounds, pick the best player and then work on the holes. There will always be holes.
One year I took 2 Wr's with my first 2 picks. My rb position was weak all year, so I concentrated on that in the later rounds in hopes of getting sleepers, but my 3 wr's helped me make it to the playoffs. I never really recovered from the weak backfield, but I didn't reach and grab a second or third tier rb.